Form D Raw Data - Electronic Filing Depository

EFDID: 572090EFD: Raw Data

Issuer: SPRUCE BIOSCIENCES, INC. (0001683553) - D

Accession: 0001683553-25-000003 () (EDGAR Files) (Form D)

Edgar Posted: Oct. 16, 2025
EFD Posted: Oct. 17, 2025

- < edgarSubmission >

< schemaVersion > X0708 </ schemaVersion >

< submissionType > D </ submissionType >

< testOrLive > LIVE </ testOrLive >

- < primaryIssuer >

< cik > 0001683553 </ cik >

< entityName > SPRUCE BIOSCIENCES, INC. </ entityName >

- < issuerAddress >

< street1 > 611 GATEWAY BOULEVARD, SUITE 740 </ street1 >

< city > SOUTH SAN FRANCISCO </ city >

< stateOrCountry > CA </ stateOrCountry >

< stateOrCountryDescription > CALIFORNIA </ stateOrCountryDescription >

< zipCode > 94080 </ zipCode >

</ issuerAddress >

< issuerPhoneNumber > (415) 655-4168 </ issuerPhoneNumber >

< jurisdictionOfInc > DELAWARE </ jurisdictionOfInc >

- < issuerPreviousNameList >

< value > None </ value >

</ issuerPreviousNameList >

- < edgarPreviousNameList >

< value > None </ value >

</ edgarPreviousNameList >

< entityType > Corporation </ entityType >

- < yearOfInc >

< overFiveYears > true </ overFiveYears >

</ yearOfInc >

</ primaryIssuer >

- < relatedPersonsList >

- < relatedPersonInfo >

- < relatedPersonName >

< firstName > Javier </ firstName >

< lastName > Szwarcberg </ lastName >

</ relatedPersonName >

- < relatedPersonAddress >

< street1 > c/o Spruce Biosciences, Inc. </ street1 >

< street2 > 611 Gateway Boulevard, Suite 740 </ street2 >

< city > South San Francisco </ city >

< stateOrCountry > CA </ stateOrCountry >

< stateOrCountryDescription > CALIFORNIA </ stateOrCountryDescription >

< zipCode > 94080 </ zipCode >

</ relatedPersonAddress >

- < relatedPersonRelationshipList >

< relationship > Executive Officer </ relationship >

< relationship > Director </ relationship >

</ relatedPersonRelationshipList >

< relationshipClarification />

</ relatedPersonInfo >

- < relatedPersonInfo >

- < relatedPersonName >

< firstName > Bali </ firstName >

< lastName > Muralidhar </ lastName >

</ relatedPersonName >

- < relatedPersonAddress >

< street1 > c/o Spruce Biosciences, Inc. </ street1 >

< street2 > 611 Gateway Boulevard, Suite 740 </ street2 >

< city > South San Francisco </ city >

< stateOrCountry > CA </ stateOrCountry >

< stateOrCountryDescription > CALIFORNIA </ stateOrCountryDescription >

< zipCode > 94080 </ zipCode >

</ relatedPersonAddress >

- < relatedPersonRelationshipList >

< relationship > Director </ relationship >

</ relatedPersonRelationshipList >

< relationshipClarification />

</ relatedPersonInfo >

- < relatedPersonInfo >

- < relatedPersonName >

< firstName > Daniel </ firstName >

< lastName > Spiegelman </ lastName >

</ relatedPersonName >

- < relatedPersonAddress >

< street1 > c/o Spruce Biosciences, Inc. </ street1 >

< street2 > 611 Gateway Boulevard, Suite 740 </ street2 >

< city > South San Francisco </ city >

< stateOrCountry > CA </ stateOrCountry >

< stateOrCountryDescription > CALIFORNIA </ stateOrCountryDescription >

< zipCode > 94080 </ zipCode >

</ relatedPersonAddress >

- < relatedPersonRelationshipList >

< relationship > Director </ relationship >

</ relatedPersonRelationshipList >

< relationshipClarification />

</ relatedPersonInfo >

- < relatedPersonInfo >

- < relatedPersonName >

< firstName > Michael </ firstName >

< lastName > Grey </ lastName >

</ relatedPersonName >

- < relatedPersonAddress >

< street1 > c/o Spruce Biosciences, Inc. </ street1 >

< street2 > 611 Gateway Boulevard, Suite 740 </ street2 >

< city > South San Francisco </ city >

< stateOrCountry > CA </ stateOrCountry >

< stateOrCountryDescription > CALIFORNIA </ stateOrCountryDescription >

< zipCode > 94080 </ zipCode >

</ relatedPersonAddress >

- < relatedPersonRelationshipList >

< relationship > Executive Officer </ relationship >

< relationship > Director </ relationship >

</ relatedPersonRelationshipList >

< relationshipClarification />

</ relatedPersonInfo >

- < relatedPersonInfo >

- < relatedPersonName >

< firstName > Simpson </ firstName >

< lastName > Camilla </ lastName >

</ relatedPersonName >

- < relatedPersonAddress >

< street1 > c/o Spruce Biosciences, Inc. </ street1 >

< street2 > 611 Gateway Boulevard, Suite 740 </ street2 >

< city > South San Francisco </ city >

< stateOrCountry > CA </ stateOrCountry >

< stateOrCountryDescription > CALIFORNIA </ stateOrCountryDescription >

< zipCode > 94080 </ zipCode >

</ relatedPersonAddress >

- < relatedPersonRelationshipList >

< relationship > Director </ relationship >

</ relatedPersonRelationshipList >

< relationshipClarification />

</ relatedPersonInfo >

- < relatedPersonInfo >

- < relatedPersonName >

< firstName > Tiba </ firstName >

< lastName > Aynechi </ lastName >

</ relatedPersonName >

- < relatedPersonAddress >

< street1 > c/o Spruce Biosciences, Inc. </ street1 >

< street2 > 611 Gateway Boulevard, Suite 740 </ street2 >

< city > South San Francisco </ city >

< stateOrCountry > CA </ stateOrCountry >

< stateOrCountryDescription > CALIFORNIA </ stateOrCountryDescription >

< zipCode > 94080 </ zipCode >

</ relatedPersonAddress >

- < relatedPersonRelationshipList >

< relationship > Director </ relationship >

</ relatedPersonRelationshipList >

< relationshipClarification />

</ relatedPersonInfo >

- < relatedPersonInfo >

- < relatedPersonName >

< firstName > Kirk </ firstName >

< lastName > Ways </ lastName >

</ relatedPersonName >

- < relatedPersonAddress >

< street1 > c/o Spruce Biosciences, Inc. </ street1 >

< street2 > 611 Gateway Boulevard, Suite 740 </ street2 >

< city > South San Francisco </ city >

< stateOrCountry > CA </ stateOrCountry >

< stateOrCountryDescription > CALIFORNIA </ stateOrCountryDescription >

< zipCode > 94080 </ zipCode >

</ relatedPersonAddress >

- < relatedPersonRelationshipList >

< relationship > Director </ relationship >

</ relatedPersonRelationshipList >

< relationshipClarification />

</ relatedPersonInfo >

- < relatedPersonInfo >

- < relatedPersonName >

< firstName > Samir </ firstName >

< lastName > Gharib </ lastName >

</ relatedPersonName >

- < relatedPersonAddress >

< street1 > c/o Spruce Biosciences, Inc. </ street1 >

< street2 > 611 Gateway Boulevard, Suite 740 </ street2 >

< city > South San Francisco </ city >

< stateOrCountry > CA </ stateOrCountry >

< stateOrCountryDescription > CALIFORNIA </ stateOrCountryDescription >

< zipCode > 94080 </ zipCode >

</ relatedPersonAddress >

- < relatedPersonRelationshipList >

< relationship > Executive Officer </ relationship >

</ relatedPersonRelationshipList >

< relationshipClarification />

</ relatedPersonInfo >

- < relatedPersonInfo >

- < relatedPersonName >

< firstName > Percival </ firstName >

< lastName > Barretto-Ko </ lastName >

</ relatedPersonName >

- < relatedPersonAddress >

< street1 > c/o Spruce Biosciences, Inc. </ street1 >

< street2 > 611 Gateway Boulevard, Suite 740 </ street2 >

< city > South San Francisco </ city >

< stateOrCountry > CA </ stateOrCountry >

< stateOrCountryDescription > CALIFORNIA </ stateOrCountryDescription >

< zipCode > 94080 </ zipCode >

</ relatedPersonAddress >

- < relatedPersonRelationshipList >

< relationship > Director </ relationship >

</ relatedPersonRelationshipList >

< relationshipClarification />

</ relatedPersonInfo >

</ relatedPersonsList >

- < offeringData >

- < industryGroup >

< industryGroupType > Biotechnology </ industryGroupType >

</ industryGroup >

- < issuerSize >

< revenueRange > No Revenues </ revenueRange >

</ issuerSize >

- < federalExemptionsExclusions >

< item > 06b </ item >

</ federalExemptionsExclusions >

- < typeOfFiling >

- < newOrAmendment >

< isAmendment > false </ isAmendment >

</ newOrAmendment >

- < dateOfFirstSale >

< value > 2025-10-09 </ value >

</ dateOfFirstSale >

</ typeOfFiling >

- < durationOfOffering >

< moreThanOneYear > false </ moreThanOneYear >

</ durationOfOffering >

- < typesOfSecuritiesOffered >

< isEquityType > true </ isEquityType >

< isOptionToAcquireType > true </ isOptionToAcquireType >

< isOtherType > true </ isOtherType >

< descriptionOfOtherType > Equity offering includes common stock and pre-funded warrants to purchase common stock. </ descriptionOfOtherType >

</ typesOfSecuritiesOffered >

- < businessCombinationTransaction >

< isBusinessCombinationTransaction > false </ isBusinessCombinationTransaction >

< clarificationOfResponse />

</ businessCombinationTransaction >

< minimumInvestmentAccepted > 0 </ minimumInvestmentAccepted >

- < salesCompensationList >

- < recipient >

< recipientName > Leerink Partners LLC </ recipientName >

< recipientCRDNumber > 39011 </ recipientCRDNumber >

< associatedBDName > None </ associatedBDName >

< associatedBDCRDNumber > None </ associatedBDCRDNumber >

- < recipientAddress >

< street1 > 53 State Street, 40th Floor </ street1 >

< city > Boston </ city >

< stateOrCountry > MA </ stateOrCountry >

< stateOrCountryDescription > MASSACHUSETTS </ stateOrCountryDescription >

< zipCode > 02109 </ zipCode >

</ recipientAddress >

- < statesOfSolicitationList >

< value > All States </ value >

</ statesOfSolicitationList >

< foreignSolicitation > false </ foreignSolicitation >

</ recipient >

- < recipient >

< recipientName > Citizens JMP Securities, LLC </ recipientName >

< recipientCRDNumber > 22208 </ recipientCRDNumber >

< associatedBDName > None </ associatedBDName >

< associatedBDCRDNumber > None </ associatedBDCRDNumber >

- < recipientAddress >

< street1 > 101 California Street, Suite 1700 </ street1 >

< city > San Francisco </ city >

< stateOrCountry > CA </ stateOrCountry >

< stateOrCountryDescription > CALIFORNIA </ stateOrCountryDescription >

< zipCode > 94111 </ zipCode >

</ recipientAddress >

- < statesOfSolicitationList >

< value > All States </ value >

</ statesOfSolicitationList >

< foreignSolicitation > false </ foreignSolicitation >

</ recipient >

- < recipient >

< recipientName > H.C. Wainwright & Co., LLC </ recipientName >

< recipientCRDNumber > 375 </ recipientCRDNumber >

< associatedBDName > None </ associatedBDName >

< associatedBDCRDNumber > None </ associatedBDCRDNumber >

- < recipientAddress >

< street1 > 430 Park Avenue, 3rd Floor </ street1 >

< city > New York </ city >

< stateOrCountry > NY </ stateOrCountry >

< stateOrCountryDescription > NEW YORK </ stateOrCountryDescription >

< zipCode > 10022 </ zipCode >

</ recipientAddress >

- < statesOfSolicitationList >

< value > All States </ value >

</ statesOfSolicitationList >

< foreignSolicitation > false </ foreignSolicitation >

</ recipient >

</ salesCompensationList >

- < offeringSalesAmounts >

< totalOfferingAmount > 49999768 </ totalOfferingAmount >

< totalAmountSold > 49999768 </ totalAmountSold >

< totalRemaining > 0 </ totalRemaining >

< clarificationOfResponse />

</ offeringSalesAmounts >

- < investors >

< hasNonAccreditedInvestors > false </ hasNonAccreditedInvestors >

< totalNumberAlreadyInvested > 21 </ totalNumberAlreadyInvested >

</ investors >

- < salesCommissionsFindersFees >

- < salesCommissions >

< dollarAmount > 3000000 </ dollarAmount >

</ salesCommissions >

- < findersFees >

< dollarAmount > 0 </ dollarAmount >

</ findersFees >

< clarificationOfResponse />

</ salesCommissionsFindersFees >

- < useOfProceeds >

- < grossProceedsUsed >

< dollarAmount > 0 </ dollarAmount >

</ grossProceedsUsed >

< clarificationOfResponse > The Company shall use the net proceeds of the sale of the Securities hereunder for non-clinical and clinical development activities for its product candidate, pre-commercial activities and general corporate purposes. </ clarificationOfResponse >

</ useOfProceeds >

- < signatureBlock >

< authorizedRepresentative > false </ authorizedRepresentative >

- < signature >

< issuerName > SPRUCE BIOSCIENCES, INC. </ issuerName >

< signatureName > /s/ Samir Gharib </ signatureName >

< nameOfSigner > Samir Gharib </ nameOfSigner >

< signatureTitle > President & CFO </ signatureTitle >

< signatureDate > 2025-10-16 </ signatureDate >

</ signature >

</ signatureBlock >

</ offeringData >

</ edgarSubmission >